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Mechanism of vascular endothelial growth factor on the prevention of restenosis after angioplasty

Qigong LIU, Honglian ZHOU, Yan ZENG, Shan YE, Jiani LIU, Zaiying LU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 177-180 doi: 10.1007/s11684-009-0021-x

Abstract: To evaluate the mechanism of vascular endothelial growth factor (VEGF) on the prevention of restenosisangioplasty, the recombinant adenovirus vector containing hVEGF cDNA was constructed and transfected into vascularThen, the VSMC and human umbilical vein endothelial cells (HUVEC) were divided into control group, H

Keywords： vascular endothelial growth factors     restenosis     reactive oxygen species     endothelial cells     vascular smooth    

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Role of nitric oxide in biological effects of vascular endothelial growth factor

Qigong LIU M D , Yan ZENG , Jiani LIU , Shan YE , Yongdong LI , Zaiying LU M D ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 284-286 doi: 10.1007/s11684-009-0062-1

Abstract: To evaluate the role of nitric oxide in the biological effects of vascular endothelial growth factor(VEGF) and the possible mechanism of VEGF, the cultured vascular endothelial cells of rabbit aorta wereThe absorbance () value of vascular endothelial cells and the levels of prostaglandin (PGI), endothelin-1 (ET-1) and von Willebrand factor (vWF) in the supernatant were observed by water-soluble tetrazoliumendothelial cells by VEGF.

Keywords： vascular endothelial growth factor     nitric oxide     N-nitro-L-arginine methyl ester     vascular endothelial    

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Changes in Lipoprotein Lipase in the Heart Following Diabetes Onset Review

Chae Syng Lee, Yajie Zhai, Brian Rodrigues

Engineering 2023, Volume 20, Issue 1,   Pages 19-25 doi: 10.1016/j.eng.2022.06.013

Abstract: To then move LPL to the endothelial cell (EC) lumen, glycosylphosphatidylinositol-anchored high-densitylipoprotein-binding protein 1 (GPIHBP1) attaches to interstitial LPL and transfers it to the vascularmoderate diabetes, with the reduction in glucose utilization, the heart increases its LPL activity at the vascularThis coincides with the loss of a cardioprotective growth factor—namely, vascular endothelial growthfactor B (VEGFB).

Keywords： Cardiac metabolism     Lipoprotein lipase     Heparanase     Vascular endothelial growth factor     Diabetic cardiomyopathy    

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Lymphatic metastasis is related to the epithelial-mesenchymal transition and expressions of VEGF, MMP-9, and COX-2 in breast cancer

Lihui WANG, Lianhong LI, Shen LV, Shujun FAN, Li ZHAN, Bo WANG, Zhong ZHANG

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 164-170 doi: 10.1007/s11684-009-0038-1

Abstract: The expressions of E-cadherin (E-Cad), N-cadherin (N-Cad), vascular endothelial cell growth factor (VEGF

Keywords： epithelial-mesenchymal transition     vascular endothelial cell growth factor     matrix metalloproteinase-9    

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lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 317-329 doi: 10.1007/s11684-022-0931-4

Abstract: Here, we investigated the role of the lncRNA growth arrest-specific 5 (lncR-GAS5) in atherogenesis.decreased LC3II/LC3I protein ratio and an elevated P62 level in lncR-GAS5-overexpressing human aortic endothelialMoreover, serine/arginine-rich splicing factor 10 (SRSF10) knockdown increased the LC3II/LC3IMechanistically, lncR-GAS5 regulated the downstream splicing factor SRSF10 to impair autophagyIn conclusion, lncR-GAS5 overexpression arrested endothelial autophagy through the miR-193-5p/SRSF10

Keywords： lncR-GAS5     miR-193-5p     splicing factor SRSF10     autophagy     atherogenesis    

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Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

Jichun Yang, Kaiyue Jin, Jiajun Xiao, Jing Ma, Duan Ma

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 403-409 doi: 10.1007/s11684-017-0522-y

Abstract:

Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor-mediated coagulationTFPI is expressed by endothelial and smooth muscle cells in the vasculature.However, the role of endogenous TFPI in vascular smooth muscle cells (VSMCs) in thrombosis and vascularPlasma TFPI concentration was also detected in the TFPITie2 (mice deleted TFPI in endothelial

Keywords： arterial thrombosis     conditional knockout mice     tissue factor pathway inhibitor     vascular smooth muscle    

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Expression of PC-cell-derived growth factor in breast cancer

Haiping SONG MD, Lan SHI MD, Chunping LIU MD, Tao HUANG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 426-430 doi: 10.1007/s11684-009-0085-7

Abstract: This study is mainly aimed at evaluating the expression of PC-cell-derived growth factor (PCDGF) in breast

Keywords： PC-cell-derived growth factor     breast neoplasms     clinical markers    

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The relationship between platelet-derived growth factor expression and angiogenesis/lymphangiogenesis

Guocheng LIU MD, Shouhua YANG MD, Zehua WANG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 447-451 doi: 10.1007/s11684-009-0082-x

Abstract: This paper is aimed to examine if changes in platelet-derived growth factor (PDGF) expression at different

Keywords： cervical cancer     lymphatic vessel density     blood vessel density     platelet-derived growth factor    

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Involvement of p38 mitogen-activated protein kinase in the regulation of platelet-derived growth factor

GONG Xiaowei, WEI Jie, LI Yusheng, CHENG Weiwei, DENG Peng, JIANG Yong

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 248-252 doi: 10.1007/s11684-007-0047-x

Abstract: the role of p38 mitogen-activated protein kinase (MAPK) in cell migration induced by platelet-derived growthfactor (PDGF).

Keywords： control     stimulation     mitogen-activated     growth factor     process    

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Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

Huating Li, Jing Zhang, Weiping Jia

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 25-30 doi: 10.1007/s11684-013-0244-8

Abstract:

Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor family.It actually functions as endocrine hormones but does not regulate cell growth and differentiation.Moreover, FGF21 also plays important roles in some physiological processes, such as fasting and feeding, growth

Keywords： FGF21     metabolism     pharmacology     physiology     clinical relevance    

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An investigation on prevalent strategies for XFEM-based numerical modeling of crack growth in porous

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 4,   Pages 914-936 doi: 10.1007/s11709-021-0750-8

Abstract: Crack growth modeling has always been one of the major challenges in fracture mechanics.Finally, the crack growth is modeled in a natural porous media (Fontainebleau sandstone).Both strategies are reliable and highly accurate in calculating the stress intensity factor, but thetests showed that the second strategy is a more accurate strategy in predicting the preferred crack growth

Keywords： numerical modeling     extended finite element method     porous media     crack growth     stress intensity factor    

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monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis through inhibition of transforming growthfactor β-induced Smad signaling

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 445-455 doi: 10.1007/s11684-014-0378-3

Abstract: dysfunction, cardiac fibrosis and cardiac fibroblast activation but did not block TAC-induced transforming growthfactor-β1 (TGF-β1) production and phosphorylation of Smad2/3.

Keywords： PDE5     cardiac fibrosis     TGF-β     CREB    

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Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor

Wenjie Zhu, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 208-220 doi: 10.1007/s11684-020-0795-4

Abstract: New targeted therapies have been developed to overcome resistance to endocrine therapy (ET) and improve the outcome of HR /HER2 advanced breast cancer (ABC). We conducted a meta-analysis and systemic review on randomized controlled trials evaluating various targeted therapies in combination with ET in HR /HER2 ABC. PUBMED and EMBASE databases were searched for eligible trials. Hazard ratios (HRs) for progression-free survival (PFS), odds ratios (ORs) for objective response rate (ORR), clinical benefit rate (CBR), and toxicity were meta-analyzed. Twenty-six studies with data on 10 347 patients were included and pooled. The addition of cyclin-dependent kinase 4/6 inhibitors to ET significantly improved median PFS (pooled HR= 0.547, <0.001), overall survival (pooled HR= 0.755, <0.001), and tumor response rates (ORR, pooled OR= 1.478, <0.001; CBR, pooled OR= 1.201, <0.001) with manageable toxicities (pooled OR= 3.280, <0.001). The mammalian targets of rapamycin inhibitors and exemestane were not clinically beneficial for this pooled population including ET-naïve and ET-resistant patients. Moderate improvement in PFS (pooled HR= 0.686, <0.001) yet pronounced toxicities (pooled OR= 2.154, <0.001) were noted in the combination of phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitors with fulvestrant. Future studies are warranted to optimize the population and the dosing sequence of these available options.

Keywords： endocrine-resistant     HR+/HER2- advanced breast cancer     randomized clinical trials     meta-analysis     targeted therapy    

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FGF23 associated bone diseases

Eryuan Liao

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 65-80 doi: 10.1007/s11684-013-0254-6

Abstract:

Recently, fibroblast growth factor 23 (FGF23) has sparked widespread interest because of its potential

Keywords： fibroblast growth factor 23     FGF receptor     phosphate metabolism     Klotho     bone disease    

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Prokaryotic expression and bioactivity analysis of growth hormone and insulin-like growth factor-I from

Xu Yongjiang,Zang Kun,Liu Xuezhou,Shi Bao and Chen Shengyi

Strategic Study of CAE 2015, Volume 17, Issue 1,   Pages 67-73

Abstract:

The mature peptide domain of insulin-like growth factor-I from Platichthys stellatus were amplifiedThe present results would be helpful for better understanding the roles of IGF-I in growth regulationand development of high effective additive for growth promotion of Platichthys stellatus.

Keywords： Platichthys stellatus； insulin-like growth factor-I； prokaryotic expression； bioactivity    

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Title Author Date Type Operation

Mechanism of vascular endothelial growth factor on the prevention of restenosis after angioplasty

Qigong LIU, Honglian ZHOU, Yan ZENG, Shan YE, Jiani LIU, Zaiying LU

Journal Article

Role of nitric oxide in biological effects of vascular endothelial growth factor

Qigong LIU M D , Yan ZENG , Jiani LIU , Shan YE , Yongdong LI , Zaiying LU M D ,

Journal Article

Changes in Lipoprotein Lipase in the Heart Following Diabetes Onset

Chae Syng Lee, Yajie Zhai, Brian Rodrigues

Journal Article

Lymphatic metastasis is related to the epithelial-mesenchymal transition and expressions of VEGF, MMP-9, and COX-2 in breast cancer

Lihui WANG, Lianhong LI, Shen LV, Shujun FAN, Li ZHAN, Bo WANG, Zhong ZHANG

Journal Article

lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

Journal Article

Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

Jichun Yang, Kaiyue Jin, Jiajun Xiao, Jing Ma, Duan Ma

Journal Article

Expression of PC-cell-derived growth factor in breast cancer

Haiping SONG MD, Lan SHI MD, Chunping LIU MD, Tao HUANG MD,

Journal Article

The relationship between platelet-derived growth factor expression and angiogenesis/lymphangiogenesis

Guocheng LIU MD, Shouhua YANG MD, Zehua WANG MD,

Journal Article

Involvement of p38 mitogen-activated protein kinase in the regulation of platelet-derived growth factor

GONG Xiaowei, WEI Jie, LI Yusheng, CHENG Weiwei, DENG Peng, JIANG Yong

Journal Article

Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

Huating Li, Jing Zhang, Weiping Jia

Journal Article

An investigation on prevalent strategies for XFEM-based numerical modeling of crack growth in porous

Journal Article

monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis through inhibition of transforming growthfactor β-induced Smad signaling

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Journal Article

Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor

Wenjie Zhu, Binghe Xu

Journal Article

FGF23 associated bone diseases

Eryuan Liao

Journal Article

Prokaryotic expression and bioactivity analysis of growth hormone and insulin-like growth factor-I from

Xu Yongjiang,Zang Kun,Liu Xuezhou,Shi Bao and Chen Shengyi

Journal Article